Table 2. Effect of maternal exposure to constant light and maternal melatonin replacement on the circadian rhythms and integrated mRNA expression of Bmal1, Per2, StAR, Mt1 and Egr1 in the rat fetal adrenal gland.

	LD			LL			LL+Mel
	φ (hours)	r2	AUC (2−ΔΔCt/24 h)	φ (hours)	r2	AUC (2−ΔΔCt/24 h)	φ (hours)	r2	AUC (2−ΔΔCt/24 h)
Per2	12.7±0.3	0.71	1.8±0.22	-	-	8.0±0.5*	9.7±0.2#	0.72	1.7±0.3
Bmal1	22.1±0.6	0.64	3.0±0.3	-	-	17.7±1.2*	22.9±0.5	0.70	2.3±0.2
StAR	6.2±0.4	0.66	1031±107	-	-	2517±154*	6.6±0.5	0.64	1191±129
Mt1	7.3±0.3	0.71	2.1±0.2	-	-	1.6±0.1*	6.3±0.2	0.70	0.6±0.1
Egr1	9.4±0.4	0.62	7.5±0.7	-	-	1.6±0.2*	5.3±0.5#	0.62	6.2±0.9

LD, mothers under light-dark cycle 12∶12 (n = 4/clock time). LL, mothers under constant lights between 10 and 18 days of gestation (n = 5/clock time). LL+Mel, Mothers under LL receiving a daily oral dose of melatonin (n = 5/clock time).

^*: Different from LD and LL+Mel (P<0.05, ANOVA and Newman-Keuls).

^#: Different from LD (Student t test).