Table 1. Quantification of fold change in cortical transcript levels in APPswePS1dE9 mice compared age-matched WT.

	3 month	6 month	9 month	12 month	15 month	18 month	9–18 month
Gfap-α	1.58	2.39	4.88***	5.74***	6.33***	5.80***	5.27***
Gfap-β	0.70	2.29	1.95	3.44*	1.27	1.93	1.94**
Gfap-γ	0.97	2.22	2.05*	3.43***	6.51***	5.25***	4.06***
Gfap-δ	1.00	1.98	3.21***	4.75***	5.98***	4.35***	4.32***
Gfap-κ	0.84	2.80	2.29**	2.43**	7.31***	6.06***	6.07***
Gfap-ζ	0.84	2.39*	2.50**	4.33***	6.10***	3.02***	3.68***
Gfap-Δ135 1	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.
Gfap-Δ164	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.
Gfap-ΔEx6 1	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.
Gfap-ΔEx7 2	n.s.	n.s.	P<0.031	n.s.	P<0.0005	P<0.028	4.07***
Vim	1.07	1.33	1.38*	1.60***	2.21***	1.95**	1.72***
Nes	0.72	0.99	1.46	1.10	1.07	0.68	1.10
Synm H	1.17	0.98	1.32	1.11	1.11	0.90	1.07
Synm M	1.21	0.90	1.28	1.15	1.19	0.99	1.12
Aldh1l1	1.20	1.12	1.04	1.04	0.92	0.75	0.88
Glul	1.00	1.07	0.92	0.95	0.80	0.96	0.89
Glt1	1.03	0.63	1.44	1.34	1.16	1.14	1.27
Glast1	0.88	0.99	1.56	1.04	1.05	0.92	1.12
S100β	0.91	1.05	1.13	1.12	1.00	1.09	1.13
Fgfr3	1.09	1.05	1.11	1.02	1.28	0.74	1.00
Sox2	1.00	0.95	1.56	0.87	0.93	1.01	1.06

^* P<0.05;

^** P<0.01;

^*** P<0.001;

Pooled data from 9–18 month old mice: n = 25 to AD; n = 38 to WT; n.d., not detectable.

¹Gfap-Δ135 and Gfap-ΔEx6 assays lack sensitivity to detect levels lower than 0.003% of the Gfap-α expression level.

²Gfap-ΔEx7 was not detectable in all of the samples and fold change therefore fluctuates. The fold change is only presented for the pooled data from the 9–18 month groups; Mann-Whitney test was used for statistical analysis with non-detectable level set at 0; n.s., non significant.

Data are presented as fold change of APPswePS1dE9 mice compared to expression levels found in WT mice of the same age.