Table 2. Genome-wide analyses of STAT3-binding sites.
| Cells | Method | Number of binding sites | Co-occupied sites with Oct4, Sox2 and Nanog |
Reference |
|---|---|---|---|---|
| mESCs | ChIP sequencing | 2546 | Oct4, Sox2 and Nanog 718 | [40] |
| mESCs | ChIP-chip with promoter arrays | 948 | Oct4 58 Nanog 114 Oct4 and Nanog 29 |
[102] |
| NIH 3T3 cells treated with oncostain M to activate the Stat3 gene |
ChIP subcloning for sequencing | Approximately 400 | Not tested | [156] |
| mESCs | DNA microarray | 58 genes activated by STAT3 overexpression |
Not tested | [105] |