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Spontaneous GC formation in ERα-/- mice in the absence of antigen challenge. Sections obtained from the spleens of 1-year-old WT (A and C) and ERα-/- (B and D) mice revealed lymphoid follicles (B220 positive, A and B). In ERα-/- mice, spontaneous formation of PNA-positive GC occurs (D), whereas WT mice exhibit poorly formed GCs (C). Arrowheads point to GC.
