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. 2004 Jan 26;101(6):1720–1724. doi: 10.1073/pnas.0307915100

Fig. 5.

Fig. 5.

Lack of ERα causes an accumulation of plasma B cells in the kidney and spleen. (A) Severe infiltration of B lymphocytes in kidneys from ERα-/- mice (hematoxylin/eosin-stained). Some of these lymphocytes are characterized as a plasma B cells with bigger cytosolic areas (A) and cytosolic IgG signals (anti-IgG positive, B). Increased numbers of plasma B cells bearing cytosolic IgG are found in spleens from ERα-/- mice (D) but not in WT mice (C). Plasma B cells also accumulate in lymph nodes from ERα-/- mice (E). Arrowheads point to plasma B cells.