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. 2004 Feb 2;101(6):1731–1736. doi: 10.1073/pnas.0305763101

Fig. 2.

Fig. 2.

Analysis of the ERVWE1 LTRs in the human population. (a) Phylogenetic analysis of the U3 region of 5′ ([5]) and 3′ ([3]) HERV-W LTRs derived from 24 amplified ERVWE1 loci (HERVWE1, 11 sequences), one bacterial artificial chromosome clone containing the ERVWE1 locus (bold letters), the PH74 placental cDNA clone containing a full-length env ORF (underlined), and two other HERV-W LTRs (HERV-WHS14-[3], HERV-W8-[3]). Neighbor-joining trees were based on 244 nucleotides, and all-gap removal was used. Bootstrap values for 500 replicated trees are indicated. (b) Relative activities of ERVWE1 5′ (HERVWE1 [5]) and 3′ (HERVWE1 [3]) LTRs, and other HERV-W 3′ LTRs (HERV WHS14 [3], HERV W8 [3]) in choriocarcinoma BeWo b30 cell line in absence (gray bar) or presence (black bar) of forskolin and in lung fibroblastic LC5 cell line (white bar). Control, basic vector without LTR.