Table 2.
STOP-PD Subjects' Demographic and Clinical Characteristics of Completer and Non-Completer Subtypes
| Variable | Total Sample | Completers | Discontinuation due to: | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Lack of Efficacy | Tolerability | Other Reasons | |||||||
| Investigator Initiated | Not Investigator Initiated | ||||||||
| N | 259 | 142 | 37 | 20 | 13 | 47 | |||
| Continuous Variables | Mean (SD) | ANOVA | |||||||
| F | df | P | |||||||
| Age (years) | 57.9 (17.7) | 57.7 (16.9) | 60.5 (18.4) | 65.5 (11.5) | 68.2 (12.7) | 50.7 (20.2) | 4.41 | 4,254 | 0.001 |
| Education (years) | 12.5 (3.4) | 12.6 (3.3) | 12.6 (3.6) | 13.6 (3.9) | 10.8 (4.7) | 12.6 (3.3) | 1.31 | 4,251 | 0.26 |
| Duration of current depressive episode (months) | 11.9 (25.4) | 12.7 (30.1) | 12.5 (23.0) | 11.4 (18.2) | 12.3 (16.9) | 8.9 (15.0) | 0.21 | 4,251 | 0.93 |
| SADS delusion severity score | 5.8 (0.9) | 5.7 (0.9) | 5.9 (0.8) | 5.8 (1.1) | 6.0 (0.6) | 5.6 (1.0) | 1.03 | 4,254 | 0.39 |
| MMSE (17-item) total score | 27.1 (3.0) | 27.0 (3.1) | 26.4 (3.2) | 27.5 (2.6) | 25.8 (2.7) | 27.1 (3.1) | 0.93 | 4,248 | 0.44 |
| CIRSG total score | 5.0 (4.0) | 4.5 (3.7) | 5.1 (3.6) | 6.4 (4.3) | 7.0 (5.1) | 5.1 (4.5) | 1.88 | 4,252 | 0.11 |
| HAM-D total score | 30.0 (5.2) | 29.4 (5.4) | 31.1 (5.4) | 32.2 (4.9) | 27.6 (3.9) | 29.3 (4.8) | 2.43 | 4,254 | 0.04 |
| BPRS total score | 54.1 (10.1) | 54.1 (10.1) | 57.6 (10.0) | 55.4 (11.9) | 51.6 (11.4) | 55.9 (9.2) | 1.34 | 4,254 | 0.25 |
| Suicide Ideation Scale sum of first 5 items | 2.4 (3.0) | 2.3 (2.8) | 2.1 (3.2) | 2.2 (3.1) | 1.8 (3.0) | 3.4 (3.7) | 1.46 | 4,254 | 0.21 |
| Categorical Variables | N (%) | X2 | df | p | |||||
| Gender---Male | 93 (35.9) | 48 (33.8) | 12 (32.4) | 10 (50.0) | 2 (10.0) | 21 (44.6) | 6.14 | 4 | 0.18 |
| Hispanic Ethnicity | 30 (11.6) | 16 (11.2) | 3 (8.1) | 3 (15.0) | 1 (5.0) | 7 (14.8) | 1.37 | 4 | 0.84 |
| Race | 10.14 | 8 | 0.25 | ||||||
| White | 218(84.2) | 121(85.2) | 32(86.5) | 19(95.0) | 12(92.3) | 34(72.3) | |||
| Black | 29(11.2) | 15(10.6) | 4(10.8) | 0(0) | 0(0) | 10(21.3) | |||
| Asian | 12(4.6) | 6(4.2) | 1(2.7) | 1(5.0) | 1(7.7) | 3(6.4) | |||
| Marital Status | 22.51 | 1 | 0.03 | ||||||
| Married | 106(40.9) | 38(26.8) | 10(27.0) | 3(15.0) | 0(0) | 16(34.0) | |||
| Single | 67(25.9) | 62(43.7) | 11(29.7) | 14(70.0) | 6(46.2) | 13(27.7) | |||
| Widowed | 49(18.9) | 23(16.2) | 11(29.7) | 3(15.0) | 3(23.1) | 9(19.1) | |||
| Divorced/Separated | 37(14.3) | 19(13.4) | 5(13.5) | 0(0) | 4(30.8) | 9(19.1) | |||
| Living Arrangements | 4.80 | 4 | 0.30 | ||||||
| Lives Alone | 57(22) | 28(19.7) | 12(32.4) | 2(10.0) | 3(23.1) | 12(25.5) | |||
| Lives with Others | 202(78) | 114(80.3) | 25(67.6) | 18(90.0) | 10(76.9) | 35(74.5) | |||
| Entry Status | 13.35 | 4 | 0.009 | ||||||
| Inpatient | 179(69.1) | 88(62.0) | 33(89.2) | 15(75.0) | 7(53.8) | 36(76.6) | |||
| Other | 80(30.9) | 54(38.0) | 4(10.8) | 5(25.0) | 6(46.2) | 11(23.4) | |||
| Treatment | 8.13 | 4 | 0.08 | ||||||
| Olanzapine + Sertraline | 129(49.8) | 81(57.0) | 18(48.6) | 8(40.0) | 4(30.8) | 18(38.3) | |||
| Olanzapine + Placebo | 130(50.2) | 61(43.0) | 19(51.4) | 12(60.0) | 9(69.2) | 29(61.7) | |||
| Lifetime Episodes of Major Depression | 1.62 | 4 | 0.80 | ||||||
| 1 | 78(30.1) | 47(33.1) | 11(29.7) | 5(25.0) | 3(23.1) | 12(25.5) | |||
| >1 | 181(69.9) | 95(66.9) | 26(70.3) | 15(75.0) | 10(76.9) | 35(74.5) | |||
| Consent | 8.91 | 4 | 0.06 | ||||||
| Surrogate | 49(18.9) | 19(13.4) | 12(32.4) | 5(25.0) | 4(30.8) | 9(19.1) | |||
| Self | 210(81.1) | 123(86.6) | 25(67.6) | 15(75.0) | 9(69.2) | 38(80.9) | |||
SADS: Schedule for Affective Disorders and Schizophrenia; MMSE: Mini-Mental State Examination; CIRS-G: Cumulative Illness Rating Scale-Geriatrics; HAM-D: Hamilton Depression Rating Scale; BPRS: Brief Psychiatric Rating Scale