Administration of 5Z-7-oxozeaenol decreased stroke severity when measured at 7 days following stroke in both WT and AMPK KO mice. a. IP administration of 5Z-7-oxozeaenol (5 mg/kg) to WT mice after stroke led to a statistically significant reduction in cortical (p = 0.028) and whole-hemisphere (p = 0.049), but not striatal (p = 0.117) stroke volume (n = 8 vehicle, 8 drug). b. IP administration of 5Z-7-oxozeaenol (5 mg/kg) to AMPK KO mice after stroke led to a statistically significant reduction in cortical (p = 0.008) and whole-hemisphere (p = 0.037) infarct volume (n = 11 vehicle, 9 drug), but not striatal (p = 0.066, n = 11 vehicle, 9 drug). Data presented as mean ± s.e.m. * p < 0.05.