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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Exp Neurol. 2012 Jun 5;237(1):238–245. doi: 10.1016/j.expneurol.2012.05.019

Figure 5.

Figure 5

Drug treatment reduced levels of activated TAK1, activated JNK, total JNK, and activated c-Jun, but not total TAK1, activated AMPK, or COX-2. a. Levels of phosphorylated TAK1 (activated form) were decreased by drug treatment during stroke (n = 5 vehicle shams, 6 vehicle strokes, 5 drug shams, 5 drug strokes). b. Quantitation of phospho-TAK1 western blots. c. Levels of total TAK1 were unchanged following stroke or drug administration (n = 5 vehicle shams, 6 vehicle strokes, 5 drug shams, 5 drug strokes). d. Quantitation of TAK1 western blots. e. Levels of pTAK1/TAK1 were decreased by stroke in drug-treated groups. Levels were unchanged by drug treatment (n = 8 vehicle shams, 10 vehicle strokes, 8 drug shams, 8 drug strokes). f. Quantitation of pTAK1/TAK1 western blots. g. Levels of phosphorylated AMPK (activated form) were unchanged by drug treatment before stroke (n = 7 vehicle shams, 9 vehicle strokes, 7 drug shams, 9 drug strokes). h. Quantitation of phospho-AMPK western blots. i. Levels of phosphorylated JNK (activated form) were decreased by drug treatment before stroke (n = 5 vehicle shams, 6 vehicle strokes, 5 drug shams, 5 drug strokes). j. Quantitation of phospho-JNK western blots. k. Levels of total JNK were not significantly changed by drug treatment or by stroke (n = 8 vehicle shams, 10 vehicle strokes, 8 drug shams, 8 drug strokes). l. Quantitation of JNK western blots. m Levels of pJNK/JNK were increased by drug treatment in sham groups (n = 8 vehicle shams, 10 vehicle strokes, 8 drug shams, 8 drug strokes). n. Quantitation of pJNK/JNK western blots. o. Levels of phosphorylated c-Jun (activated form) were decreased by drug treatment before stroke. (n = 2 vehicle shams, 2 drug shams, 3 vehicle strokes, 3 drug strokes). p. Quantitation of phospho-c-Jun western blots. q. Levels of COX-2 were increased following stroke, but were not affected by drug treatment (n = 2 vehicle shams, 2 drug shams, 3 vehicle strokes, 3 drug strokes). r. Quantitation of COX-2 western blots. Data presented as mean ± s.e.m. * p < 0.05.