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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Fam Cancer. 2012 Sep;11(3):381–385. doi: 10.1007/s10689-012-9523-9

Table 2.

Classification of BRCA1/2 variants identified in 146 high-risk families

Gene Non-pathogenic Class 1 or 2 Pathogenic Class 4 or 5 Unclassified Class 3 VUS Intronic variants
Class 1 or 2 Class 4 or 5 Unclassified
BRCA1 21 1 18 0 0 3
BRCA2 28 0 43 2 0 5

Note: three probands have both BRCA1 and BRCA2 VUS.