Table 1. Transcripts with ≥1.5-fold altered expression in left atrial tissue of 3-day postoperative pigs versus controls.
Transcripts are separated into down-regulated (upper) and upregulated (lower), and sorted by F (signal-to-noise ratio). Pre-filtered to remove low-intensity signals (<5.0 in both Control and Postop groups). KHDRBS3, KH domain containing, RNA binding, signal transduction associated 3; CAPRIN 2, Cytoplasmic activation/proliferation-associated protein 2; SH3BGRL, SH3 domain binding glutamic acid-rich protein like.
| DOWNREGULATED POST-OP
| ||||
|---|---|---|---|---|
| Gene name | Fold-change | P value | F | Protein name |
| KCNE1 | −2.01 | 0.009 | 14.4 | KCNE1 (MinK) |
| NPPB | −2.15 | 0.01 | 13.8 | Natriuretic peptide B precursor |
| PTX3 | −4.08 | 0.03 | 8.05 | Pentraxin 3 |
| NPR3 | −1.51 | 0.03 | 7.93 | Natriuretic peptide receptor C |
| AOPEP | −1.69 | 0.03 | 7.78 | Aminopeptidase O isoform 1 |
| ADCY5 | −1.55 | 0.041 | 6.68 | Adenylyl cyclase type V |
| FHL1C | −1.51 | 0.045 | 6.34 | FHL1 isoform C |
| NESTIN | −1.55 | 0.045 | 6.34 | Nestin |
| PDPN | −1.89 | 0.046 | 6.32 | Podoplanin |
| HOMER2 | −1.59 | 0.049 | 6.07 | Homer 2 |
|
| ||||
| UPREGULATED POST-OP
| ||||
| Gene name | Fold-change | P value | F | Protein name |
|
| ||||
| TNM2 | 1.52 | 0.001 | 35.3 | Teneurin-2 |
| PDGFRL | 1.61 | 0.005 | 19.1 | Platelet-derived growth factor receptor-like |
| CCC7 | 2.02 | 0.006 | 16.7 | Complement Component C7 |
| MYLIP | 1.66 | 0.01 | 13.9 | Myosin regulatory light chain interacting protein |
| CD34 | 1.71 | 0.02 | 11.1 | Hematopoietic progenitor cell antigen CD34 |
| FBLN1 | 1.76 | 0.02 | 11.0 | Fibulin 1 |
| FCER1A | 1.56 | 0.02 | 10.7 | IgE Fc receptor subunit gamma |
| DSCR5 | 2.65 | 0.02 | 10.3 | Down Syndrome Critical Region 5 |
| ALOX5 | 1.54 | 0.02 | 9.8 | Arachidonate 5-lipoxygenase |
| CRIg | 2.03 | 0.02 | 9.8 | Complement receptor of the Ig superfamily |
| TBC1D5 | 1.56 | 0.02 | 9.7 | TBC1 domain family, member 5 |
| ATRNL1 | 1.68 | 0.02 | 9.1 | Attractin-like protein 1 |
| ASAH1 | 1.57 | 0.03 | 8.8 | Acid ceramidase |
| PIK3CG | 1.59 | 0.03 | 8.7 | PIP3-kinase catalytic subunit g |
| KHDRBS3 | 1.51 | 0.03 | 7.6 | KHDRBS3 |
| C1R | 1.91 | 0.03 | 7. 4 | Complement C1r |
| MS4A6D | 2.05 | 0.04 | 7. 2 | 4-span TM protein 3 |
| C3 | 1.58 | 0.04 | 6.9 | Complement C3a anaphylatoxin |
| CAPRIN-2 | 1.52 | 0.04 | 6.6 | CAPRIN 2 |
| CDNF | 1.94 | 0.04 | 6.6 | Cerebral dopamine neurotrophic factor |
| TNNI1 | 1.84 | 0.046 | 6.3 | Troponin I |
| SH3BGRL | 1.58 | 0.047 | 6.2 | SH3BGRL |
| EMCN | 1.68 | 0.049 | 6.0 | Endomucin |