Table 1.
Demographic and laboratory characteristics of subjects
| Definite CSS (n=8 ) | Probable CSS (n=21) | HES <2 ACR with asthma or sinusitis (n=20) | HES <2 ACR No asthma or sinusitis (n=18) | Normals (n=8) | |
|---|---|---|---|---|---|
| Median age§ (range) | 45 (22–55) | 55 (22–75) | 49 (19–82) | 59 (30–76) | 43 (28–54) |
| Gender (M/F) | 5/3 | 7/14 | 9/11 | 10/8 | 2/6 |
| Median serum IgE§ (range) | 128 (9–856) | 213 (18–2600) | 266 (4–23000) | 99.1 (14–5022) | ND |
| Median equivalent prednisone dose§ (mg) | 10 (0–40) | 10 (0–60) | 3.6 (0–60) | 2.8 (0–20) | 0 |
| Median CRP§ (range) | 1.03 (0.51–31) | 2.9 (0.91–29.7) | 1.42 (0.43–18.5) | 0.7 (0.28–5.73) | ND |
| Median ESR§ (range) | 11 (2–72) | 14 (3–77) | 7.5 (2–90) | 7 (2–90) | ND |
| Median BVAS§ (range) | 5.5 (2–13) | NA | NA | NA | NA |
| Median B12§ (range) | 834 (339–1312) | 742.5 (285–1699) | 681 (201–1383) | 637 (316–1603) | ND |
| Median AEC§ (range) | 515 (115–5810) | 570 (0–3162) | 547 (40–6878) | 1145 (30–3680) | 140 (37–340) |
| Median peak eosinophil count¶ (range) | 9452 (1300–17000) | 4900 (716–48080) | 3400 (1000–40000) | 5366 (1800–21080) | NA |
| Median duration of eosinophilia¶ (years) | 5 | 4 | 3 | 6 | NA |
| Median ALC§ (range) | 1603 (824–4111) | 1812.5 (950–5090) | 1600 (340–3940) | 1490 (618–3940) | ND |
| Median tryptase§ (range) | 5.4 (1.78–10.5) | 4.24 (1.31–28.1) | 6.51 (1.47–33.1) | 5.65 (1.67–6067) | ND |
Abbreviations: ACR, American College of Rheumatology, AEC, absolute eosinophil count, ALC- absolute lymphocyte count, BVAS- Birmingham vasculitis activity score CRP- C reactive protein, CSS, Churg Strauss Syndrome, ESR-Erythrocyte sedimentation rate, HES- Hypereosinophilic syndrome, HESwAS-Hypereosinophilic syndrome with asthma and/or sinusitis. ND-No data, NA-Not applicable.
§
Data collected at the time of the serum collection
¶
Data collected over the course of the disease process and follow-up.