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. Author manuscript; available in PMC: 2013 Oct 15.
Published in final edited form as: Exp Cell Res. 2012 Jun 13;318(17):2215–2225. doi: 10.1016/j.yexcr.2012.06.006

Figure 2. Migration and invasion capabilities of cybrid cells in the presence of non-specific MMP inhibitor GM6001.

Figure 2

Migration transwell assays were performed using uncoated inserts and invasion assay was conducted on inserts coated with matrigel. (a) The bar graph represents the average numbers of cybrid cells migrated through uncoated inserts in the presence of 20μM GM6001. (b) Representative microscopic pictures of stained cells that migrated through the pores of the uncoated inserts in the presence or absence of GM6001. (c) The bar graph shows the average of cells invading through the matrigel-coated inserts in the presence of 20μM GM6001. (d) Representative microscopic pictures of stained cells that invaded through the pores of matrigel coated inserts in the presence or absence of GM6001.The cybrid cells were assayed in triplicate transwells for each experiment, and the averages were graphed with the standard error of the mean (SEM). The asterisks indicate that mtBALB cybrid cells showed a statistically significant decrease in migration and invasion from the mtB6 in the presence of non-specific MMP inhibitor GM6001. *P value < 0.05, **P value < 0.005.