Table 3. Selected list of genes with higher expression in mtBALB cybrids relative to mtB6 cybrids based on category of interest.

Potential targets with absolute value of the fold change (FC) higher than 1.5 were selected. MMP-9 (in bold) was selected for further studies. Log (FC) means the logarithm of fold change at the base 2. Positive log (FC) values correspond with up-regulation of selected genes. Three individual clones of mtB6 and mtBALB cybrid cells were assayed for each Agilent subarray.

Category of interest	Gene name	Public ID	Gene symbol	Log (FC)	Absolute value of FC
Inflammatory response/Cytokine activity	chemokine (C-C motif) ligand 5 rantes, complete cds chemokine (C-C motif) ligand 20 glucose phosphate isomerase 1 CD28 antigen lymphocyte antigen 96	NM_013653 M77747 NM_016960 NM_008155 NM_007642 NM_016923	Ccl5 Rantes Ccl20 Gpi1 Cd28 Ly96	1.09 1.27 1.80 0.88 2.29 0.62	2.13 2.41 3.48 1.84 4.89 1.54
Cell adhesion	camello-like 4 camello-like 5 dystonin, transcript variant b Von Willebrand factor homolog collagen, type XVI, alpha 1 vascular cell adhesion molecule 1 collagen, type VIII, alpha 1	NM_023455 NM_023493 NM_134448 NM_011708 NM_028266 NM_011693 NM_007739	Cml4 Cml5 Dst Vwf Col16a1 Vcam1 Col8a1	1.45 1.05 0.65 0.69 0.61 0.70 0.65	2.73 2.07 1.57 1.61 1.53 1.62 1.57
Skeletal system development/Metalloendopeptidase activity	matrix metallopeptidase 9 a disintegrin-like and marallopgptidase (reprolysin type) with thrombospondin type 1 motif, 7 O-sialoglycoprotein endopeptidase-like 1	NM_013599 NM_001003911 NM_028091	Mmp9 Adamts7 Osgepl1	1.55 0.86 0.59	2.93 1.82 1.51
Isomerase activity	thioredoxin domain containing 10 glucuronyl C5-epimerase	NM_198295 NM_033320	Txndc10 Glce	0.60 1.11	1.52 2.16
Angiogenesis/Cell differentiation	angiopoietin-like 6	NM_145154	Angptl6	0.69	1.61
Transferase activity	nicotinamide nucleotide adenylyltransferase 3 nicotinamide N-methyltransferase monoacylglycerol O-acyltransferase 1 integrin beta 1 binding protein 3 glucosamine-phosphate N-acetyltransferase 1 aldehyde dehydrogenase 1 family, member L2 glutathione S-transferase, alpha 2 glutathione S-transferase, alpha 1 (Ya)	NM_144533 NM_010924 NM_026713 NM_027120 NM_019425 NM_153543 NM_008182 NM_008181	Nmnat3 Nnmt Mogat1 Itgb1bp3 Gnpnat1 Aldh1l2 Gsta2 Gsta1	1.31 1.20 1.01 1.01 0.91 0.89 0.84 0.90	2.48 2.30 2.01 2.01 1.88 1.85 1.79 1.87
Oxidoreductase activity	aldo-keto reductase family 1, member B7 cytochrome c oxidase, subunit VI a, polypeptide 2 cytochrome b5 reductase 1 phytanoyl-CoA dioxygenase domain containing 1 FAD-dependent oxidoreductase domain containing 1 dehydrogenase/reductase (SDR family) member 7	NM_009731 NM_009943 NM_028057 NM_172267 NM_172291 NM_025522	Akr1b7 Cox6a2 Cyb5r1 Phyhd1 Foxred1 Dhrs7	1.49 1.35 1.05 1.03 0.67 0.59	2.81 2.55 2.07 2.04 1.59 1.51