Table 4.
Microbicides | Status | Phase | Type of prevention | Alternate study ID | Component | Comment/references |
---|---|---|---|---|---|---|
NCT00262106 | Complete | III | Gel, vaginal | MDP301, ISRCTN64716212 | PRO 2000/5 gel 0.5% and 2% | Not efficacious; McCormack et al., 2010 |
NCT00153777 | Terminated | III | Gel, vaginal | CONRAD, C03-090 | Cellulose sulfate gel (6%) | No protection, possible enhancement; Van Damme et al., 2008 |
NCT00213083 | Unknown | III | Gel, vaginal | Population council #322 | Carraguard (PC-515) | No protection; Skoler-Karpoff et al., 2008 |
NCT00441298 | Complete | II | Gel, vaginal | CAPRISA 004 | Tenofovir 1% gel | 39% efficacy; Abdool Karim et al., 2010 |
NCT00705679 | Active | II | Gel, vaginal and ART oral | VOICE, MTN-003 | Tenofovir 1% vaginal gel, emtricitabine/tenofovir disoproxil fumarate | Vaginal gel arm halted, no efficacy; 1 |
NCT00740584 | Complete | I/II | Gel, vaginal | SPL7013-003, DAIDS ES number 10730 | 3% SPL7013 gel (VivaGel) | Price et al., 2011 |
NCT00850837 | Recruiting | I | Gel, vaginal | AF 020 | Acidform lubricant (Amphora) | – |
NCT01283360 | Recruiting | I | Gel, rectal | CONRAD, 1009001 | Tenofovir 1% gel | – |
More information about the individual trials can be found using the NCT number and the following databases: www.aidsinfo.nih.gov/clinical-trials; www.clinicaltrials.gov; http://www.avac.org.
1. http://www.niaid.nih.gov/news/newsreleases/2011/Pages/VOICEdiscontinued.aspx