Table 1. Immunophenotypic features of gastrointestinal mesenchymal tumors.
| Diagnosis | KIT | DOG1 | Desmin | SMA | h-Cal | S100 | CD34 | HMB45 | EMA | β-Cat | Clusterin | Keratin | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GIST |
+++ |
+++ |
- |
++ (40)* |
++ |
- |
+++ |
- |
- |
- |
- |
- |
|
| Leiomyoma |
- |
- |
+++ |
+++ |
+++ |
- |
- |
- |
- |
- |
- |
- |
|
| Leiomyosarcoma |
- |
- |
+ to ++ |
+++ |
++ |
- |
+ (10) |
- |
- |
- |
- |
- |
|
| Schwannoma |
- |
- |
- |
- |
- |
+++ |
- |
- |
- |
- |
- |
- |
GFAP |
| Fibromatosis |
- |
- |
- |
++ |
- |
± |
- |
- |
- |
++ |
- |
- |
|
| Synovial sarcoma |
- |
- |
- |
- |
- |
++ (30) |
- |
- |
++ |
- |
- |
± |
|
| PEComa |
- |
- |
++ |
++ |
- |
- |
- |
+++ |
- |
- |
- |
- |
Melan-A |
| FDCS |
- |
- |
- |
- |
- |
± |
- |
- |
± |
- |
+++ |
- |
CD21/23/35 |
| Dermatofibroma |
- |
- |
- |
+++ |
- |
- |
+++ |
- |
- |
++ |
- |
- |
|
| IFP |
- |
- |
- |
± |
- |
- |
++ |
- |
- |
- |
- |
- |
|
| IMT |
- |
- |
- |
++ |
- |
- |
± |
- |
- |
- |
- |
- |
ALK-1 |
| SFT | - | - | - | + | - | - | +++ | - | - | - | - | - |
*Parenthetical numbers represent approximate percentage of cases that are positive. Abbreviations: SMA, smooth muscle actin; h-Cal, h-Caldesmon; -Cat, -Catenin; PEComa, Perivascular epithelioid cell tumour; FDCS, Follicular dendritic cell sarcoma; IFP, Inflammatory fibroid polyp; IMT, Inflammatory myofibroblastic tumor; SFT, Solitary fibrous tumor; -, negative stain; ±, sometimes positive and sometimes negative stain; +, <25% of cases positive; ++, 25-50% of cases positive; +++, >50% of cases positive