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Molecular pathways in colorectal tumorigenesis. CRC, colorectal cancer; MSS, microsatellite stable; MSI-H, high level microsatellite instability; FAP, familial adenomatous polyposis; AFAP, attenuated FAP; PJS, Peutz-Jeghers syndrome; JPS, juvenile polyposis syndrome; MAP, MUTYH-associated polyposis; CIN, chromosomal instability pathway; MSI, microsatellite instability; CIMP, CpG island methylator phenotype; ?, pathways yet undefined
