Table 2.
Univariable and multivariable analyses of factors associated with disease free survival in the full cohort, women and men
| Disease free survival |
Univariable |
Multivariable |
||||
|---|---|---|---|---|---|---|
| All HR(95%CI) | Women HR(95%CI) | Men HR(95%CI) | All HR(95%CI) | Women HR(95%CI) | Men HR(95%CI) | |
|
Age |
|
|
|
|
|
|
| Continuous |
1.01 (0.97-1.05) |
1.00 (0.95-1.05) |
1.01 (0.95-1.07) |
0.98 (0.94-1.02) |
1.00 (0.94-1.06) |
1.00 (0.92-1.09) |
|
Sex |
|
|
|
|
|
|
| Women |
1.00 |
- |
- |
1.00 |
- |
- |
| Men |
1.51 (0.85-2.70) |
- |
- |
1.06 (0.52-2.15) |
- |
- |
|
Histological subtype |
|
|
|
|
|
|
| LMM + SSM |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| NMM |
5.63 (3.15-10.08) |
6.36 (2.67-15.12) |
5.39 (2.41-12.09) |
1.21 (0.55-2.63) |
1.47 (0.48-4.54) |
1.49 (0.46-4.82) |
|
Breslow thickness |
|
|
|
|
|
|
| <=1 mm |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| > 1 mm |
8.44 (4.27-16.68) |
12.17 (4.07-36.34) |
6.12 (2.14-14.73 |
0.61 (0.10-3.70) |
0.17 (0.01-2.95) |
1.45 (0.15-14.22) |
|
Clark level |
|
|
|
|
|
|
| II-III |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| IV-V |
3.75 (2.11-6.69) |
6.28 (2.65-14.89) |
2.37 (1.07-5.22) |
0.52 (0.26-1.03) |
1.04 (0.32-3.43) |
0.36 (0.12-1.07) |
|
Ulceration |
|
|
|
|
|
|
| No |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| Yes |
5.82 (3.13-10.80) |
5.90 (2.41-14.42) |
7.21 (2.97-17.48) |
1.56 (0.65-3.76) |
0.70 (0.23-2.12) |
5.46 (1.70-17.53) |
|
Clinical stage |
|
|
|
|
|
|
| 1 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| 2-4 |
15.02 (16.39-35.30) |
25.41 (5.81-111.08) |
11.76 (3.86-35.87) |
5.56 (3.02-24.28) |
6.88 (1.64-28.89) |
6.39 (1.56-26.25) |
|
Vascular invasion |
|
|
|
|
|
|
| No |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| Yes |
9.25 (3.56-17.79) |
20.48 (5.47-76.65) |
6.87 (2.96-15.97) |
3.44 (1.63-7.25) |
4.79 (1.21-19.01) |
11.15 (3.42-36.38) |
|
Mitotic count |
|
|
|
|
|
|
| 0/mm2 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| > = 1/mm2 |
7.95 (3.56-17.80) |
27.24 (3.65-203.10) |
4.83 (1.92-12.13) |
3.28 (1.11-9.73) |
6.87 (0.77-61.05) |
2.21 (0.53-9.13) |
|
Lymphocytic infiltrate |
|
|
|
|
|
|
| None-mild |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| Moderate-brisk |
0.43 (0.24-0.78) |
0.45 (1.19-1.08) |
0.43 (0.19-0.94) |
0.73 (0.37-1.44) |
0.87 (0.31-2.43) |
0.69 (0.25-1.90) |
|
Ki67 expression |
|
|
|
|
|
|
| 0-25% |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| >25% | 2.46 (1.33-4.56) | 1.67 (0.67-4.15) | 4.06 (1.74-9.48) | 1.74 (0.85-3.54) | 0.96 (0.24-3.78) | 6.14 (1.76-21.39) |
LMM = lentigo maligna melanoma, SSM = superficial spreading melanoma, NMM = nodular malignant melanoma.