Table 3.
Univariable and multivariable analyses of factors associated with overall survival in the full cohort, women and men
| Overall |
Univariable |
Multivariable |
||||
|---|---|---|---|---|---|---|
| All HR(95%CI) | Women HR(95%CI) | Men HR(95%CI) | All HR(95%CI) | Women HR(95%CI) | Men HR(95%CI) | |
|
Age |
|
|
|
|
|
|
| Continuous |
1.09 (1.04-1.13) |
1.08 (1.02-1.15) |
1.08 (1.02--1.14) |
1.07 (1.02-1.13) |
1.09 (1.02-1.16) |
1.10 (1.02-1.18) |
|
Sex |
|
|
|
|
|
|
| Women |
1.00 |
- |
- |
1.00 |
- |
- |
| Men |
2.60 (1.47-4.61) |
- |
- |
1.89 (0.95-3.79) |
- |
- |
|
Histological subtype |
|
|
|
|
|
|
| LMM + SSM |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| NMM |
3.86 (2.21-6.74) |
3.93 (1.54-10.03) |
4.17 (2.06-8.44) |
2.73 (1.38-5.40) |
3.35 (1.25-8.95) |
2.88 (1.21-6.84) |
|
Breslow thickness |
|
|
|
|
|
|
| <=1 mm |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| > 1 mm |
4.17 (2.38-7.32) |
4.53 (1.74-11.79) |
3.66 (1.83-7.34) |
0.73 (0.16-3.42) |
0.56 (0.04-7.58) |
0.58 (0.08-4.28) |
|
Clark level |
|
|
|
|
|
|
| II-III |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| IV-V |
2.27 (1.28-4.05) |
1.87 (0.66-5.25) |
2.22 (1.11-4.44) |
0.84 (0.36-1.92) |
0.53 (0.15-1.88) |
1.10 (0.35-3.41) |
|
Ulceration |
|
|
|
|
|
|
| No |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| Yes |
6.29 (4.46-11.45) |
5.83 (2.14-15.85) |
7.33 (3.44-15.62) |
2.63 (1.19-5.83) |
1.01 (0.18-5.76) |
3.34 (1.30-8.60) |
|
Clinical stage |
|
|
|
|
|
|
| 1 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| 2-4 |
6.48 (3.05-13.73) |
5.48 (1.43-21.04) |
6.34 (2.49-16.14) |
1.71 (0.57-5.08) |
2.54 (0.59-10.89) |
0.59 (0.11-3.29) |
|
Vascular invasion |
|
|
|
|
|
|
| No |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| Yes |
4.89 (2.38-4.08) |
13.43 (2.84-63.50) |
2.82 (1.23-6.50) |
4.54 (1.90-10.84) |
19.95 (3.63-109.75) |
4.89 (1.66-14.41) |
|
Mitotic count |
|
|
|
|
|
|
| 0/mm2 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| > = 1/mm2 |
2.96 (1.66-5.28) |
3.54 (1.26-9.96) |
2.86 (1.41-5.82) |
1.49 (0.65-3.40) |
1.63 (0.34-7.81) |
1.34 (0.44-4.07) |
|
Lymphocytic infiltrate |
|
|
|
|
|
|
| None-mild |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| Moderate-brisk |
0.46 (0.26-0.79) |
0.53 (0.17-1.09) |
0.45 (0.22-0.90) |
0.66 (0.35-1.25) |
1.03 (0.30-3.49) |
0.60 (0.27-1.35) |
|
Ki67 expression |
|
|
|
|
|
|
| 0-25% |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
1.00 |
| >25% | 1.97 (1.06-3.64) | 1.79 (0.66-4.87) | 2.38 (1.09-5.22) | 1.55 (0.73-3.30) | 1.46 (0.34-6.14) | 2.65 (1.08-6.52) |
LMM = lentigo maligna melanoma, SSM = superficial spreading melanoma, NMM = nodular malignant melanoma.