Table 1.
Summary of human liver eQTL studies.
| Category | Schadt et al. | Innocenti et al. | Schroder et al. | Greenawalt et al. |
|---|---|---|---|---|
| Samples in final analysis (n) | 384 | 206 | 149 | 651 |
| Race | All Caucasian | 183 European American 23 African American | All Caucasian | 86% of overall cohort Caucasian |
| Nature of liver tissue | Postmortem tissue and resections from donor livers | Postmortem tissue and resections from donor livers | Normal tissue resected during surgery for liver cancer | Tissue from morbidly obese patients undergoing gastric bypass |
| Covariates | Age, sex and medical center | Age, sex, genetic ancestry, effects of array hybridization and oligonucleotide probes, and surrogate variables | Age, sex, smoking, alcohol consumption, diagnosis, C-reactive protein, cholestatic liver disease and presurgical medication | Age, sex and medical center |
| Genotyping platform (GEO dataset) | Affymetrix 500 k Illumina 650Y (GSE# n/a) | Illumina 610 Quad (GSE26105) | Illumina HumanHap300 (GSE39036) | Illumina 650Y (GSE# n/a) |
| Expression platform (GEO dataset) | Agilent Custom 44k (GSE9588) | Agilent 4×44k (GSE25935) | Illumina HumanWG-6 v2.0 (GSE32504) | Agilent Custom 44k (GSE24293) |
| cis-eQTLs (n) | 1350 (Bonferroni adjusted) 3210 (FDR<10%) | 1787 (BF>5) | 1179 (Bonferroni adjustment) | 7902 (FDR<10%) |
| trans-eQTLs (n) | 242 (Bonferroni adjustment) 491 (FDR<10%) | 353 (BF>5) | 47 (Bonferroni adjustment) | 785 (FDR<10%) |