Table 2.

Liver eQTLs of PharmGKB ‘very important pharmacogenes’^a.

Pharmacogene	eSNP	eQTL study	PharmGKB pharmacogenetic SNPsb sharing perfect LDc (r2 = 1) with liver eSNP
			Pharmacogenetic SNP	Related drug(s)
COMT	rs174674	Schadt et al.	−	−
CYP2D6	rs151096	Schadt et al.	−	−
	rs8138080	Schadt et al.	−	−
	rs133337	Innocenti et al.	−	−
CYP3A4	rs7792939	Greenawalt et al.	−	−
CYP3A5	rs10242455	Schadt et al. Schroder et al.	rs4646457 rs776746	Tacrolimus Cyclosporine Nevirapine Paclitaxel Rosuvastatin Sirolimus Sunitinib Tacrolimus
	rs1859690	Schadt et al. Schroder et al.	rs4646457 rs776746	Tacrolimus Tacrolimus Cyclosporine Nevirapine Paclitaxel Rosuvastatin Sirolimus Sunitinib
MTHFR	rs1801131	Innocenti et al.	rs1801131	Methotrexate Nitrous oxide
UGT1A1	rs2070959	Schroder et al.	−	–
VKORC1	rs2303222	Innocenti et al.	rs2359612 rs8050894	Warfarin Warfarin
	rs10871454	Schroder et al.	rs2359612 rs8050894	Warfarin Warfarin
	rs889548	Schroder et al.	−	−
	rs749767	Schroder et al.	−	−
	rs4889606	Schadt et al.	−	−

^aPharmGKB has currently identified 46 genes of particular importance in pharmacogenomics (http://www.pharmgkb.org/search/browseVip.action?browseKey=vipGenes).

^bFrom the PharmGKB curated list of level 1–3 SNP-drug clinical annotations (http://www.pharmgkb.org/search/clinicalAnnotationList.action?evidenceStrength=1).

^cLD determined from 1000 Genomes Pilot 1 CEU data using SNAP browser (http://www.broadinstitute.org/mpg/snap/ldsearch.php).