Fig. 7. AS703026 is cytotoxic against CD138-purified MM cells from patients with relapsed and refractory MM.
CD138-purified patient tumor cells were treated with AS703026 for 5 days and then subjected to MTT (A) or [3H]thymidine uptake (B) assays. Data in A and B were derived from the same patient cells (MM1-8). Two patient MM cells (MM11 & MM14) were also cocultured with BMSCs in the presence or absence of drug for 5 days (C).