Fig. 2.

Early measurements of cortical contusion size were not affected by post-injury (±)-rolipram treatment. Animals received (A) vehicle (5% ethanol) or (±)-rolipram (3 mg/kg, i.v.) at (B) 30 min or (C) 3 hr after moderate parasagittal FPI, then once per day for 3 days (intraperitoneally, i.p.). Brains were analyzed at 3 days post-injury and sections were stained with H&E. Shown is bregma level −5.8 mm. Scale bars 500 μm. Scatter plot and mean ± SEM of the cortical contusion volumes (D). n = 7 vehicle-treated TBI animals, n = 6 (±)-rolipram-treated 30 min post-injury animals, n = 7 (±)-rolipram-treated 3 hr post-injury animals.