Fig. 5.

Endogenous albumin immunoreactivity increased with post-injury administration of (±)-rolipram. Animals received vehicle (5% ethanol) or (±)-rolipram (3 mg/kg, i.v.) 30 min or 3 hr after moderate parasagittal FPI, then once per day (i.p.) until perfusion. Animals were perfused at 3 days post-injury and paraffin-embedded sections were immunostained for anti-rat albumin (A). Images shown are at bregma level −4.3 mm. Scale bars 250 μm. Quantification of immunostaining (B). Endogenous albumin immunoreactivity significantly increased in (±)-rolipram-treated animals treated at either 30 min or 3 hr post-injury as compared to vehicle-treated animals. Mean ± SEM, n = 7 vehicle-treated animals, n = 5 (±)-rolipram-treated animals at 30 min post-injury, n = 5 (±)-rolipram-treated animals at 3 hr post-injury, *P < 0.05, **P < 0.01, ***P < 0.001 for TBI+vehicle versus TBI+rolipram.