TABLE II.

Significantly Enriched Pathways in the Subnetwork

Ingenuity Canonical Pathways	PBHa	Ob
TGF-β signaling	1.95×10−8	11
RAR activation	1.95×10−8	14
Molecular mechanisms of cancer	2.88×10−8	18
Prolactin signaling	2.88×10−8	10
Glucocorticoid receptor signaling	2.45×10−7	15
14-3-3-mediated signaling	1.91×10−6	10
Neurotrophin/TRK signaling	3.80×10−6	8
PPARα/RXRα activation	5.37×10−6	11
Pancreatic adenocarcinoma signaling	6.92×10−6	9
Regulation of IL-2 expression in activated and anergic T lymphocytes	7.76×10−6	8
Thrombopoietin signaling	8.13×10−6	7

^aBH: multiple testing correction by Benjamini & Hochberg (1995).

^bObserved number of module genes in the category.