Table 2. Proliferative Zone to Hypertrophic Zone.
Bioinformatic analysis of the genes changing from proliferative zone to hypertrophic zone in the growth plate cartilage of 1 wk old rats using the computer program Ingenuity Pathway Analysis 7.1.
| Upregulated Genes | No of genes |
|---|---|
| P <0.01 | 1717 |
| P <0.01, ≥ 2.0 fold | 794 |
| Biological Functions | P value | No of genes |
|---|---|---|
| Cellular Growth and Proliferation | 6.41E-10 | 234 |
| Cellular Movement | 1.26E-09 | 152 |
| Cell Death | 1.87E-09 | 213 |
| Cell Morphology | 3.28E-08 | 133 |
| Cellular Development | 3.44E-08 | 181 |
| Downregulated Genes | No of genes |
|---|---|
| P <0.01 | 1625 |
| P <0.01, ≥ 2.0 fold | 635 |
| Biological Functions | P value | No of genes |
|---|---|---|
| Cell Cycle | 5.79E-10 | 224 |
| Cellular Growth and Proliferation | 2.25E-09 | 427 |
| Cell Death | 3.86E-08 | 396 |
| Skeletal and Muscular System Development and Function | 4.74E-07 | 98 |
| Cellular Movement | 1.93E-06 | 252 |
| Functional Pathways | P value | Ratio* |
|---|---|---|
| p53 Signaling | 1.726E-03 | 19/87 (21.8%) |
| Cell Cycle: G2/M Regulation | 5.140E-03 | 10/43 (23.3%) |
| Cell Cycle: G1/S Regulation | 1.832E-02 | 12/59 (20.3%) |
| Ephrin Receptor Signaling | 3.311E-02 | 28/193 (14.5%) |
| Oncostatin M Signaling | 3.698E-02 | 8/38 (21.1%) |
| BMP Signaling | 4.385E-02 | 15/80 (18.8%) |
Ratio = number of molecules with P > 0.05/total number of molecules in the pathway