Table 3. Senescence (3 wk to 12 wk).
Bioinformatic analysis of the genes changing in the proliferative zone from 3 wk to 12 wk old rats using the computer program Ingenuity Pathway Analysis 7.1.
| Upregulated Genes | No of genes |
|---|---|
| P <0.01 | 1221 |
| P <0.01, ≥ 2.0 fold | 173 |
| Biological Functions | P value | No of genes |
|---|---|---|
| Small Molecule Biochemistry | 6.29E-06 | 25 |
| Cell Death | 6.84E-06 | 38 |
| Cell Morphology | 8.75E-06 | 46 |
| Cellular Growth and Proliferation | 2.24E-05 | 57 |
| Cellular Function and Maintenance | 4.79E-05 | 9 |
| Downregulated Genes | No of genes |
|---|---|
| P <0.01 | 1046 |
| P <0.01, ≥ 2.0 fold, | 131 |
| Biological Functions | P value | No of genes |
|---|---|---|
| Skeletal and Muscular System Development and Function | 6.91E-09 | 52 |
| Organ Development | 3.74E-06 | 24 |
| Cellular Growth and Proliferation | 1.70E-05 | 106 |
| Cardiovascular System Development and Function | 1.70E-05 | 36 |
| Tissue Development | 2.97E-05 | 72 |
| Functional Pathways | P value | Ratio* |
|---|---|---|
| Eicosanoid Signaling | 7.063E-03 | 5/84 (6.0%) |
| VDR/RXR Activation | 1.033E-02 | 7/80 (8.8%) |
| p38 MAPK Signaling | 2.301E-02 | 6/95 (6.3%) |
| Wnt/β-catenin Signaling | 3.846E-02 | 9/165 (5.5%) |
Ratio = number of molecules with P > 0.05/total number of molecules in the pathway