Table 2.

The effect of CCME on antioxidant enzymes (SOD, CAT, and GST) and nonenzymatic antioxidant, GSH in iron overloaded mice.

Treatment	SOD		CAT		GST		GSH
	Unit/mg protein	% change	Unit/mg protein	% change	Unit/mg protein	% change	μg/mg protein	% change
B	0.62 ± 0.05	—	21.55 ± 2.24	—	7.19 ± 0.71	—	0.48 ± 0.01	—
C	0.14 ± 0.07X3	77.04	10.29 ± 0.73X3	52.25	2.16 ± 0.51X3	70.02	0.32 ± 0.01X3	32.36
S50	0.26 ± 0.04X3Y1	58.58	10.59 ± 0.34X3	50.83	3.49 ± 0.67X3Y2	51.45	0.42 ± 0.02X3Y3	10.85
S100	0.31 ± 0.07X3Y2	50.72	11.81 ± 0.71X3Y1	45.21	4.87 ± 0.57X3Y3	32.21	0.45 ± 0.02Y3	5.63
S200	0.32 ± 0.05X3Y1	48.95	15.14 ± 0.77X2Y3	29.7	4.98 ± 0.68X1Y2	30.77	0.46 ± 0.01X1Y3	3.55
D	0.39 ± 0.06X3Y2	36.59	18.97 ± 0.81X1Y3	11.97	3.13 ± 0.53X3Y1	56.47	0.39 ± 0.05X3Y3	18.37

B: Normal mice; C: iron overload control; S50: iron overload + CCME (50 mg/kg b.w.); S100: iron overload + CCME (100 mg/kg b.w.); S200: iron overload + CCME (200 mg/kg b.w.); D: iron overload + desirox (20 mg/kg b.w.).

Values are mean ± SD of six observations.

X: significant difference from normal mice (B) group (X1: P ≤ 0.05; X2: P ≤ 0.01 and X3: P ≤ 0.001).

Y: significant difference from iron overloaded (C) group (Y1: P ≤ 0.05; Y2: P ≤ 0.01; Y3: P ≤ 0.001).