Figure 1.

Food- and 5-HT-dependent increases in sensitivity to dilute octanol require both MOD-1 and SER-1. Wild-type and 5-HT receptor null mutant animals were examined for their ability to respond to dilute (30%) octanol in the presence or absence of food (E. coli OP50) or 5-HT (4 mm), as described in Materials and Methods. Data are presented as mean ± SE and analyzed by a two-tailed Student's t test. ***p < 0.001; significantly different from wild-type animals under identical test conditions. Numbers of trials are indicated under the bars. Quad, ser-4(ok512); mod-1(ok103); ser-7(tm1325) ser-1(ok345); Quint, ser-5(tm2654); ser-4(ok512); mod-1(ok103); ser-7(tm1325) ser-1(ok345).