Figure 3.

Rescue of 5-HT-dependent increases in aversive responses to dilute octanol and food-dependent alterations in the rate of spontaneous reversals in ser-1 null animals. A, Wild-type or mutant animals expressing the indicated transgenes were assayed for 5-HT-dependent increases in aversive responses to dilute (30%) octanol as described in Materials and Methods. B, C, Spontaneous reversals (reversals/3 min) were quantified in well fed animals 1 min after transfer to plates without (B) or with (C) E. coli OP50. Data are presented as mean ± SE and analyzed by a two-tailed Student's t test. ***p < 0.001, significantly different from wild-type animals under identical test conditions. The number of trials is indicated under the bars, and results from rescued ser-1 null animals are indicated by hatched bars.