Figure 6.

Tentative localization of 5-HT receptors in neurons involved in ASH-mediated aversive responses to dilute octanol. The ASH sensory neurons are necessary and sufficient for responses to dilute octanol and innervate multiple levels of the locomotory circuit, including the command interneurons that control forward and backward locomotion (White et al., 1986; Chao et al., 2004). Interestingly, based on the tentative localization of different ser-x::gfp transgenes and the neuron-specific rescue/knockdown studies described above, the 5-HT receptors modulating octanol sensitivity do not appear to be expressed directly in the command interneurons but, instead, in neurons modulating their output. Direct outputs from the ASH are presented in red. Numbers are an estimate of synaptic connectives between neurons (White et al., 1986).