Figure 1.
Estimated frequency of specific genotypes in childhood ALL. Data were modified from Pui et al9 by including recently identified genotypes. The genetic lesions that are exclusively seen in cases of T-cell ALL are indicated in gold and those commonly associated with precursor B-cell ALL in blue. The darker gold or blue color indicates those subtypes generally associated with poor prognosis. BCR-ABL1–like cases can be separated into one group with CRLF2 dysregulation and the other with activating cytokine receptor and kinase signaling.