Fig 3.

P. chabaudi/P. berghei-infected animals have increased IL-10/TNF-α and IL-12/IFN-γ ratios. Plasma samples from 3 separate experiments, obtained 9 or 10 days postinfection for P. chabaudi- and sham-infected animals and P. chabaudi/P. berghei-infected animals or 6 or 7 days postinfection for P. berghei-infected animals, were analyzed with a multiplex cytokine assay. (A) Mean cytokine concentrations across groups. The P value was obtained by analysis of variance with a post hoc test for multiple comparisons. *, significant difference when comparing that group to each of the other groups except when a horizontal bar is present, in which case the difference for a single comparison was significant. (B and C) IL-10/TNF-α and IL-12/IFN-γ ratios. Only ratios where the denominator was >0 were used for this analysis. The P value was obtained using the Mann-Whitney test. All error bars represent SDs.