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bbb22 and/or bbb23 is required for B. burgdorferi mouse infectivity
| Clone | Spirochete dose per mouse | No. of infected mice/totala |
|---|---|---|
| Δbbb22-23/pBSV2G | 1 × 104 | 0/6 |
| 1 × 107 | 0/6 | |
| Δbbb22-23/pBSV2G bbb22-23 | 1 × 104 | 6/6 |
| 1 × 107 | 6/6 |
Number of infected mice per number of mice analyzed, determined 3 weeks postinoculation by positive serology against B. burgdorferi proteins and reisolation of spirochetes from ear, bladder, and joint tissues.
