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. 2012 Sep;19(9):369–374. doi: 10.1101/lm.027128.112

Figure 5.

Figure 5.

MEK activity and P-CREB undergo a circadian oscillation in the hippocampus. (A) P-MEK-1/2 expression in pooled hippocampal extracts from animals dissected at ZT8 or ZT20. (B) Quantification of P-MEK-1/2 at ZT8 and ZT20 normalized to MEK-1 protein expression. (n = 5 animals per time point). (*) P = 0.019, two-tailed t-test; error bars, SE. (C) P-CREB expression in pooled hippocampal extracts from animals dissected at ZT8 or ZT20. (D) Quantification of P-CREB phosphorylation at ZT8 and ZT20 (n = 4–5 animals per time point). (**) P < 0.001; two-tailed t-test; error bars, SE. (Adapted from Eckel-Mahan et al. 2008.)