Table 2.
Test characteristics of the Kaiser Permanente Northern California (KPNC) extent of disease (EOD) staging derivation for AJCC TNM Version 6 and SEER-modified AJCC TNM Staging Systems of female breast cancer cases diagnosed from 1996–2003 at Kaiser Permanente Southern California (KPSC)
| AJCC TNM Version 6 Staging* |
Stage 0 | Stage I | Stage II | Stage III | Stage IV | Overall‡ |
|---|---|---|---|---|---|---|
| Percent Agreement | 1.00 | 0.97 | 0.94 | 0.97 | 1.00 | 0.92 |
| (95% CI)† | (1.00, 1.00) | (0.97, 0.98) | (0.94, 0.95) | (0.97, 0.97) | (1.00, 1.00) | (0.92, 0.93) |
| Kappa Statistic | 0.99 | 0.94 | 0.88 | 0.75 | 0.94 | 0.89 |
| (95% CI)† | (0.99, 1.00) | (0.94, 0.95) | (0.87, 0.88) | (0.73, 0.77) | (0.92, 0.95) | (0.89, 0.90) |
| Sensitivity | 0.99 | 0.97 | 0.91 | 0.69 | 0.92 | Not |
| (95% CI)† | (0.99, 0.99) | (0.96, 0.97) | (0.90, 0.92) | (0.66, 0.71) | (0.90, 0.94) | calculable |
| Specificity | 1.00 | 0.98 | 0.96 | 0.99 | 1.00 | Not |
| (95% CI)† | (1.00, 1.00) | (0.97, 0.98) | (0.96, 0.97) | (0.99, 0.99) | (1.00, 1.00) | calculable |
|
SEER-modified AJCC TNM Staging* |
Stage 0 | Stage I | Stage II | Stage III | Stage IV | Overall§ |
| Percent Agreement | 1.00 | 0.98 | 0.96 | 0.97 | 1.00 | 0.95 |
| (95% CI)† | (1.00, 1.00) | (0.98, 0.98) | (0.95, 0.96) | (0.97, 0.97) | (0.99, 1.00) | (0.95, 0.96) |
| Kappa Statistic | 1.00 | 0.95 | 0.90 | 0.77 | 0.94 | 0.93 |
| (95% CI)† | (0.99, 1.00) | (0.95, 0.96) | (0.90, 0.91) | (0.75, 0.79) | (0.92, 0.95) | (0.93, 0.94) |
| Sensitivity | 1.00 | 0.98 | 0.95 | 0.72 | 0.92 | Not |
| (95% CI)† | (0.99, 1.00) | (0.98, 0.99) | (0.94, 0.96) | (0.70, 0.75) | (0.90, 0.94) | calculable |
| Specificity | 1.00 | 0.98 | 0.96 | 0.99 | 1.00 | Not |
| (95% CI)† | (1.00, 1.00) | (0.97, 0.98) | (0.95, 0.96) | (0.99, 0.99) | (1.00, 1.00) | calculable |
From the AJCC Cancer Staging Manual 6th edition [1] and the SEER Comparative Staging Guide for Cancer [7], respectively.
Test characteristics were estimated by comparing derived TNM staging data from extent of disease data in the KPSC Cancer Registry to previously collected, gold-standard TNM staging information in the KPSC Cancer Registry. Overall sensitivity and specificity were not calculable for all stages combined since these test characteristics were specific to each stage category.
Overall statistics for AJCC TNM Staging Version 6 exclude Not Applicable for mixed stage per [1]
Overall statistics for SEER-modified AJCC TNM Staging exclude Not Applicable for mixed stage and Error per [7].