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. Author manuscript; available in PMC: 2012 Aug 14.
Published in final edited form as: Transl Stroke Res. 2012 Mar 6;3(2):279–285. doi: 10.1007/s12975-012-0148-y

Figure 4.

Figure 4

Dose-response curve of MCAs from sham animals, ischemic side, and contralateral side to acetylcholine (ACh) at 2 days (A, sham: n=5; ischemic MCA: n=6; non-ischemic MCA: n=6) and 2 weeks (B & C, sham: n=5; ischemic MCA: n=7; non-ischemic MCA: n=7) after transient MCAO. Instead of dilation, ACh induced a mild dose-dependent constriction in the MCAs from both the ischemic and contralateral hemispheres at 2 weeks after stroke (B). At 2 weeks after ischemic stroke, the highest dose of ACh (10−14 M) induced 12.89 ± 13.96% dilation in MCAs from sham controls (sham MCA), −10.69 ± 10.34% and −18.26 ± 11.29% constriction in the MCAs from the ischemic (ischemic side MCA) and non-ischemic hemispheres (contralateral MCA), respectively.