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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Heart Lung Transplant. 2012 Jul 11;31(9):1018–1024. doi: 10.1016/j.healun.2012.05.018

Figure 4. Dark Agouti xeno-APCs are capable of directly stimulating B6 CD4+ T-cells.

Figure 4

MLRs were performed utilizing B6 CD4+ T-cells as responders with BALB/c γ-irradiated splenocyte allo-stimulators (positive control) or DA γ-irradiated splenocyte xeno-stimulators or media alone (control). Error bars represent the standard deviation from quadruplicate wells in the MLR assay. Each panel is representative of 3 experiments. Results show significant B6 CD4+ T-cell proliferation to both the BALB/c allo-control stimulators and the DA xeno-stimulators, thus demonstrating that xeno APCs are capable of directly stimulating CD4+ T-cells. The media controls did not elicit a significant response from B6 responders.