Temperature increase in tumor tissue with or without ICG or ICG-PL-PEG in response to irradiation of an 808-nm laser with a power density of 0.5 W/cm2 and different durations.
A. Photograph of a mouse bearing bilateral tumors.
B and D. Thermographic image and plots of average temperature increase of bilateral tumors during 808-nm laser irradiation without ICG or ICG-PL-PEG.
C and E. Thermographic image and plots of average temperature increase of bilateral tumors during 808-nm laser irradiation 3 hours after injection of ICG (left tumor) and ICG-PL-PEG (right tumor).