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. Author manuscript; available in PMC: 2013 Mar 5.
Published in final edited form as: Mol Pharm. 2012 Feb 22;9(3):514–522. doi: 10.1021/mp200526m

Figure 5.

Figure 5

Photothermal treatment of mouse tumor using intravenous injection of ICG and ICG-PL-PEG-mAb, followed by laser irradiation.

A. Photograph of a mouse bearing U87-MG tumor.

B. Thermographic images of mice bearing U87-MG tumors under different treatments.

C. Plot of maximum surface temperature of the irradiated area as a function of the irradiation time. (n=3 per group).

D. Histological staining of the excised tumors 12 hours after different treatments. Distinctive characteristics of cellular damage were observed in the Laser+ICG-PL-PEG-mAb treated tumors, including coagulative necrosis (arrow), abundant pyknosis (arrowhead) and considerable regions of karyolysis (asterisk).

E. Time-dependent tumor growth curves of U87-MG tumor. The results were presented as the arithmetic means with standard deviations of tumor volumes in each group. Only the Laser+ICG-PL-PEG-mAb treated group shows significant suppression of tumor growth compared with other experimental groups (n=3).