Table 1.
Presents the amount of time (sec ± SEM) that mice (n = 12/group) spent investigating the constant and novel objects in the novel object recognition task.
| Experiment 2 | Constant Object | Novel Object |
|---|---|---|
| Saline (i.c.v.)/Saline (i.p.) | 11 ± 2 | 18 ± 3 |
| Saline (i.c.v.)/U50,488 (0.3 mg/kg, i.p.) | 16 ± 3 | 14 ± 2 |
| NXM (30 nmol, i.c.v.)/Saline (i.p.) | 8 ± 1† | 16 ± 2 |
| NXM (30 nmol, i.c.v.)/U50,488 (0.3 mg/kg, i.p.) | 7 ± 1† | 16 ± 3 |
| Experiment 3 | Constant Object | Novel Object |
| Saline (i.c.v.)/Saline (i.p.) | 10 ± 2 | 22 ± 3 |
| Saline (i.c.v.)/ffir-NH2 (1 mg/kg, i.p.) | 12 + 3 | 22 ± 4 |
| ffir-NH2 (3 nmol, i.c.v.)/Saline (i.p.) | 8 ± 1 | 6 ± 1‡ |
| ffir-NH2 (3 nmol, i.c.v.)/nor-BNI* (5 mg/kg, i.p.) | 11 ± 2 | 19 ± 3 |
†
indicates a main effect wherein naloxone methiodide (NXM)-infused mice significantly differed from saline-infused mice on exploration of the constant object, irrespective of peripheral injection condition (p < 0.05).
‡
indicates a significant interaction wherein mice infused with ffir-NH2 significantly differed from salineinfused controls on exploration of the novel, but not constant, object (p < 0.05).
*
nor-BNI = nor-binaltorphimine