Table IIIB.

CpG sites as hallmarks of the CpG island methylator phenotype of clear cell RRCs

Target IDa	Chrb	Positionc	CpG islandd	Gene symbol	Δβ T–N (mean ± SD)		P e
					Cluster A (n = 90)	Cluster B (n = 14)
cg17162024	8	53,478,454	Y	FAM150Af	0.126±0.120	0.499±0.184	3.40 × 10−7
cg22040627	17	6,617,030	Y	SLC13A5	0.045±0.072	0.283±0.103	2.64 × 10−7
cg14859460	5	178,422,244	Y	GRM6f	0.077±0.105	0.434±0.184	1.10 × 10−7
cg09260089	10	134,599,860	Y	NKX6-2	0.078±0.083	0.372±0.150	2.26 × 10−7

aProbe ID of the Infinium HumanMethylation27 Bead Array.

bChromosome.

cNCBI Database (Genome Build 37).

dY means CpG island.

eTop four probes capable of discriminating Cluster B from Cluster A identified by random forest analysis (Supplementary Figure S5, available at Carcinogenesis Online) using the 869 probes on which the DNA methylation levels (Δβ _T–N) were differed significantly between Clusters A and B (Wilcoxon rank sum test).

fThe FAM150A and GRM6 genes were shared by Tables IIIA and IIIB.