Figure 1a. and 1b. The median concentration of SP-A and of SP-B in amniotic fluid was significantly higher at term than in the mid-trimester of pregnancy (SP-A term no labor: median 5.6 μg/ml, range 2.2–15.2 μg/ml vs. mid-trimester: median 1.64 μg/ml, range 0.1–4.7 μg/ml; p<0.001 and SP-B term no labor: median 0.54 μg/ml, range 0.17–1.99 μg/ml vs. mid-trimester: median, 0 μg/ml, range 0–0.35 μg/ml; p<0.001). The median amniotic fluid concentration of SPA in women at term in spontaneous labor was significantly lower than in those not in labor (term in labor: median 2.7 μg/ml, range 1.2–10.1 μg/ml vs. term no labor: median 5.6 μg/ml, range 2.2–15.2 μg/ml; p<0.001). There was no significant difference in the median amniotic fluid concentration of SP-B between women with and without labor (term in labor: median 0.47 μg/ml, range 0.04–1.32 μg/ml vs. term no labor: median 0.54 μg/ml, range 0.17–1.99μg/ml; p=0.2). *p<0.05.