Figure 1. Palmitoylation Sequences in E-domain of nuclear receptors. The consensus palmitoylation motif for mouse/human ER, AR, PR and GR are remarkably similar sequences with a cysteine “C” at the third position surrounded by 9–11 highly related amino acids. Ω, aromatic; ϕ, hydrophobic; ζ, hydrophilic. Number represents amino acid number from the beginning of the E-domain.⁶³