Table 1.

Effect of VBME at 100, 200 and 300mg/kg i.p. in yeast induced pyrexia

Treatment	Dosemg/kg	Rectal temperature (°C)
		After administration of drug
		Normal (A)	after 24h (B)	1h (C1)	2h (C2)	3h (C3)	4h (C4)	5h (C5)
Saline	10mL	36.66 ± 0.11	38.92 ± 0.34	38.82 ± 0.21	38.78 ± 0.11	38.68 ± 0.20	38. 68 ± 0.20	38.72 ± 0.15
Paracetamol	150mg	37.08 ± 0.08	39.46 ± 0.04	38.20** ± 0.01	37.80** ± 0.03	37.30** ± 0.02	37.35 ** ± 0.28	37.38** ± 0.04
VBME	100mg	37.06 ± 0.02	39.70 ± 0.43	39.44 ± 0.22	38.98* ± 0.22	38.04** ± 0.11	38.16** ± 0.12	38.22** ± 0.11
	200	37.00 ± 0.14	39.00 ± 0.11	38.68 ± 0.02	38.40*s ± 0.25	37.72** ± 0.45	37.80** ± 0.11	37.85 ± 0.41
	300	37.02 ± 0.12	39.84 ± 0.20	39.30 ± 0.31	38.70* ± 0.12	37.64** ± 0.44	37.74** ± 0.10	37.80** ± 0.23

Data are reported as mean ± S.E.M. for group of six animals. The data was analyzed by ANOVA followed by Dunnett’s test. Asterisks indicated statistically significant values from control. *P < 0.05, **P < 0.01.