Table 3.
Effect of VBME 100, 200 and 300mg/kg in hot plat test
| Group | Treatment/kg | 0min | 30min | 60min | 90min | 120min |
|---|---|---|---|---|---|---|
| Saline |
10ml |
9.20 ± 0.02 |
9.22 ± 0.08 |
9.16 ± 0.09 |
9.20 ± 0.03 |
9.12 ± 0.11 |
| VBME |
100mg |
9.21 ±0.23 |
11.92 ± 0.44 |
13.20* ± 0.87 |
12.78* ± 0.46 |
12.58* ± 0.34 |
| 200mg |
9.23 ±0.65 |
12.85 ± 0.87 |
14.51** ± 0.54 |
14.30** ± 0.84 |
14.09** ± 0.91 |
|
| 300mg |
9.24 ±0.76 |
19.76* ± 0.22 |
23.74** ± 0.12 |
23.10** ± 0.12 |
22.98** ± 0.69 |
|
| TramadolR |
30mg |
9.20 ±0.02 |
25.34** ± 0.04 |
25.88*** ± 0.06 |
25.80*** ± 0.07 |
25.77*** ± 0.00 |
| Analgesic effect of TramadolR and VBME antagonized by Naloxone | ||||||
| VBME |
300mg |
9.21 ±0.45 |
10.78** ± 0.56 |
10.80** ± 0.39 |
10.91** ± 0.89 |
10.98** ± 0.78 |
| 200mg |
9.22 ±0.76 |
10.80** ± 0.87 |
10.75** ± 0.92 |
10.82** ± 0.72 |
10.86** ± 0.92 |
|
| TramadolR | 30mg | 9.23 ±0.02 | 10.22** ± 0.05 | 10.02*** ± 0.09 | 10.24*** ± 0.03 | 10.05*** ± 0.00 |
Values are reported as mean ± S.E.M. for group of six animals. The data was analyzed by ANOVA followed by Dunnett’s test. Asterisks indicated statistically significant values from control. *P < 0.05, **P < 0.01, ***P < 0.001.