Table 5.
Effect of intraperitoneal administration of VBME at 100, 200 and 300mg/kg in carrageenan and histamine induced paw edema test
| Treatment | Dose mg/kg | NPS | 0h | 1h | 2h | 3h | 4h | 5h |
|---|---|---|---|---|---|---|---|---|
| Saline |
10ml |
0.0960 ± 0.22 |
0.2160 ± 0.24 |
0.2180 ± 0.12 |
0.2195 ± 0.20 |
0.2040 ± 0.14 |
0.2040 ± 0.18 |
0.2060 ± 0.17 |
| Diclofenac |
10mg |
0.0900 ± 0.20 |
0.2180 ± 0.23 |
0.1487* ± 0.02 |
0.0980** ± 0.08 |
0.0499** ± 0.03 |
0.0620** ± 0.02 |
0.0821** ± 0.06 |
|
Anti-inflammatory effect against carrageenan induced paw edema | ||||||||
| VBME |
100 |
0.0920 ± 0.24 |
0.2140 ± 0.20 |
0.2020 ± 0.09 |
0.1902 ± 0.16 |
0.1499* ± 0.35 |
0.1580 ± 0.14 |
0.1680 ± 0.24 |
| 200 |
0.0980 ± 0.18 |
0.2060 ± 0.19 |
0.1723* ± 0.27 |
0.1500* ± 0.29 |
0.0998** ± 0.31 |
0.1145* ± 0.40 |
0.1240* ± 0.20 |
|
| 300 |
0.0980 ± 0.20 |
0.2190 ± 0.22 |
0.1680* ± 0.27 |
0.1247* ± 0.32 |
0.0799** ± 0.19 |
0.0940** ± 0.37 |
0.1009** ± 0.17 |
|
|
Anti-inflammatory effect against histamine induced paw edema | ||||||||
| VBME |
200 |
0.0970 ± 0.12 |
0.2070 ± 0.42 |
0.1628* ± 0.43 |
0.1520* ± 0.21 |
0.0999** ± 0.22 |
0.1091* ± 0.31 |
0.1109* ± 0.19 |
| 300 | 0.0967 ± 0.32 | 0.2092 ± 0.53 | 0.1185* ± 0.87 | 0.1155* ± 0.24 | 0.0810** ± 0.71 | 0.0905** ± 0.33 | 0.1013** ± 0.18 | |
NPS (Normal Paw size). Values are reported as mean ± S.E.M. for group of six animals. The data was analyzed by ANOVA followed by Dunnett’s test. Asterisks indicated statistically significant values from control. *P < 0.05, **P < 0.01.