Table 3.
Analysis of viral blips in animals with low viremia during tenofovir treatment and after tenofovir withdrawal
| |
During tenofovir treatment |
After tenofovir withdrawal |
|
||||||
|
Animal numbera |
Time window (weeks of infection)b |
Number of time points for plasma viral RNA analysis |
Number of time points with plasma viral RNA ≥ 50 copies per ml |
Peak plasma virus copies per ml (time point) |
Time window (weeks of infection)b |
Number of time points for plasma viral RNA analysis |
Number of time points with plasma viral RNA ≥ 50 copies per ml |
Peak plasma virus copies per ml (time point) |
One-sidedpvalue for frequency of viremia ≥ 50 copies/ml duringversusafter tenofovir treatment |
| 29276c |
598-736 |
16 |
0 |
NAc |
NAc |
NAc |
NAc |
NAc |
NAc |
| 30577 |
299-552 |
39 |
12 |
270 (513 wks) |
553-595 wks |
40 |
7 |
1,100 (556 wks) |
p = 0.13 |
| 32186 |
316-457 |
39 |
4 |
300 (418 wks) |
458 -498 wks |
40 |
9 |
3,600 (494 wks) |
p = 0.13 |
| 33088 | 284-425 | 38 | 2 | 200 (386 wks) | 426-468 wks | 40 | 0 | 30 (435 wks) | p = 0.23 |