Table 5.
Summary of plasma and PBMC-associated virus levels shortly before and after tenofovir withdrawal
| |
30577 |
32186 |
33088 |
33091 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Plasma |
PBMC |
Plasma |
PBMC |
Plasma |
PBMC |
Plasma |
PBMC |
|||||
| Time after tenofovir withdrawal | RNA | DNA | RNA | RNA | DNA | RNA | RNA | DNA | RNA | RNA | DNA | RNA |
| - 24 wks |
< 10 |
4 |
1 |
< 10 |
1 |
< 1 |
< 10 |
4 |
4 |
4,300 |
20 |
5 |
| - 12 wks |
< 15 |
7 |
2 |
< 10 |
< 1 |
< 1 |
< 15 |
3 |
< 1 |
38,000 |
20 |
20 |
| - 4 wks |
170 |
8 |
< 2 |
< 30 |
< 1 |
< 1 |
< 30 |
4 |
1 |
42,000 |
80 |
80 |
| 0 |
< 15 |
< 3 |
< 3 |
20 |
< 1 |
< 1 |
< 15 |
< 3 |
< 3 |
62,000 |
30 |
30 |
| 3 wks |
780 |
< 2 |
< 2 |
20 |
< 3 |
< 3 |
< 15 |
< 3 |
< 3 |
120,000 |
60 |
50 |
| 4 wks |
1,100 |
< 3 |
6 |
30 |
< 3 |
< 3 |
< 15 |
4 |
3 |
53,000 |
140 |
70 |
| 8 wks |
< 30 |
7 |
2 |
< 30 |
1 |
2 |
< 30 |
3 |
8 |
41,000 |
50 |
130 |
| 12 wks |
< 12 |
2 |
< 1 |
< 12 |
1 |
< 1 |
< 12 |
4 |
< 1 |
130,000 |
50 |
50 |
| 16 wks |
120 |
8 |
< 1 |
20 |
4 |
< 1 |
< 12 |
7 |
< 1 |
70,000 |
90 |
20 |
| 24 wks |
< 10 |
10 |
< 3 |
< 10 |
6 |
< 4 |
20 |
9 |
< 4 |
100,000 |
200 |
160 |
| 32 wks |
350 |
4 |
< 1 |
< 10 |
3 |
< 1 |
< 10 |
5 |
2 |
170,000 |
150 |
270 |
| 36 wks |
15 |
7 |
< 1 |
< 10 |
7 |
< 3 |
< 10 |
3 |
< 1 |
310,000 |
170 |
120 |
| 37 wks |
< 10 |
5 |
< 1 |
3,600 |
9 |
< 4 |
< 10 |
2 |
< 1 |
460,000 |
160 |
110 |
| 39 wks |
< 10 |
10 |
< 6 |
470 |
15 |
< 3 |
< 10 |
7 |
7 |
550,000 |
180 |
430 |
| 40 wks |
20 |
4 |
< 1 |
320 |
7 |
< 4 |
< 10 |
2 |
< 1 |
650,000 |
180 |
290 |
| 41-43 wksa | < 10 | 7 | < 2 | 20 | 15 | < 1 | < 10 | 6 | < 1 | 530,000 | 280 | 470 |
Cell-free levels in plasma are expressed as RNA copies per ml plasma. Cell-associated levels are expressed as number of viral RNA and DNA copies per 100,000 cell equivalents. Values are given relative to the time of permanent tenofovir withdrawal (=time zero). Results of samples from other time points that are not shown in these tables were used for the analysis of Table 3.
aValues for 41–43 weeks after tenofovir withdrawal are those at the time of euthanasia.