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Two Alternative Models for the Role of LACS6/LACS7 Acyl-CoA Synthetase in Supplying Substrates for β-Oxidation.
(A) The ABC transporter PXA1 delivers unesterified fatty acids to the peroxisome matrix, and these are activated by LACS6/LACS7.
(B) PXA1 delivers acyl-CoAs to the peroxisome matrix, while LACS6/LACS7 activate fatty acids on an independent pathway involving fatty acid entry by diffusion or by a yet unidentified transport protein (?).
